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KMID : 0385019990150030261
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Korean Journal of Laboratory Animal Science
1999 Volume.15 No. 3 p.261 ~ p.266
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Ventriculo-peritoneal Shunting Method in Spontaneous Hydrocephalic Mouse, B 10.PL
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이철호/Lee, Chul Ho
현병화/정영길/이남섭/최창명/Hyun, Byung Hwa/Jeong, Young Gil/Lee, Nam Seob/Choi, Chang Myung
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Abstract
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Congenital hydrocephalus is most often caused by an obstruction in the cerebrospinal fluid flow pathway and results in ventricular dilatation and chronic trauma to the surrounding brain. The present study used B10.PL mouse as a model for treatment of hydrocephalus by ventriculoperitoneal shunting and investigated the extension of their life-span. As a result, the life-span in ventriculoperitoneal shunt treatment mouse is exteneded over 2 weeks more than untreatment mouse. The present study indicates that ventriculoperitoneal shunting may contribute to the improvement of the symptoms in this mouse.
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